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What (who) is N-Terminal domain antiandrogen - definition
N-Terminal domain antiandrogen
DRUG CLASS
Peptide antiandrogens; Peptide antiandrogen; N-terminal domain antiandrogen; N-terminal domain androgen receptor antagonist; N-Terminal domain androgen receptor antagonist
N-Terminal domain antiandrogens are a novel type of antiandrogen that bind to the N-terminal domain of the androgen receptor (AR) instead of the ligand-binding domain (where all currently-available antiandrogens bind) and disrupt interactions between the AR and its coregulatory binding partners, thereby blocking AR-mediated gene transcription. They are being investigated for the treatment of prostate cancer.
YgbB N terminal protein domain
In molecular biology, YgbB is a protein domain. This entry makes reference to a number of proteins from eukaryotes and prokaryotes which share this common N-terminal signature and appear to be involved in terpenoid biosynthesis.
YjeF N terminal protein domain
In molecular biology, the YjeF N terminal is a protein domain found in the N-terminal of the protein, EDC3. The YjeF N-terminal domains occur either as single proteins or fusions with other domains and are commonly associated with enzymes.
